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Lookup NU author(s): Dr David Bulmer, Professor Jeffrey Pearson
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
To determine if laryngopharyngeal reflux alters mucin gene expression in laryngeal mucosa. Methods. Insitu hybridization was employed to study the expression of the 8 well-characterised mucin genes MUC1-4, 5AC, 5B, 6, and 7 inreflux laryngeal mucosa from laryngeal ventricles, posterior commissures, and vocal folds compared to control/normal laryngealmucosa. Results. MUC1-5 genes are expressed in normal and reflux laryngeal mucosa. MUC1, 3 and 4 are expressed in respiratoryand squamous mucosa whereas MUC2 and 5AC are expressed in respiratory mucosa only. MUC3, 4 and 5AC are downregulatedin reflux mucosa. MUC5AC expression is significantly reduced in the 3 mucosal sites and when mucosal type was taken intoaccount, this remains significant in combined laryngeal and ventricular mucosa only. Conclusions. MUC3, 4 and 5AC expressionis downregulated in laryngopharyngeal reflux. This may be due to laryngeal mucosal metaplasia and/or alteration of mucin geneexpression in the preexisting mucosa. Altered mucin gene expression might predispose laryngeal mucosa to the damaging effect ofreflux
Author(s): El-Sayed Ali M, Bulmer DM, Dettmar PW, Pearson JP
Publication type: Article
Publication status: Published
Journal: International Journal of Otolaryngology
Year: 2014
Volume: 2014
Print publication date: 24/03/2014
Online publication date: 24/03/2014
Acceptance date: 25/09/2013
Date deposited: 26/10/2022
ISSN (print): 1687-9201
ISSN (electronic): 1687-921X
Publisher: Hindawi Publishing Corporation
URL: https://doi.org/10.1155/2014/264075
DOI: 10.1155/2014/264075
PubMed id: 24790604
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