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Lookup NU author(s): Dr Agnieszka Bronowska
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
By harnessing the chirality of the DNA double helix, chemists have been able to obtain new, reliable, selective, and environmentally friendly biohybrid catalytic systems with tailor-made functions. Nonetheless, despite all the advances made throughout the years in the field of DNA-based asymmetric catalysis, many challenges still remain to be faced, in particular when it comes to designing a "universal"catalyst with broad reactivity and unprecedented selectivity. Rational design and rounds of selection have allowed us to approach this goal. We report here the development of a DNA/RNA hybrid catalytic system featuring a covalently attached bipyridine ligand, which exhibits unmatched levels of selectivity throughout the current DNA toolbox and opens new avenues in asymmetric catalysis.
Author(s): Duchemin N, Aubert S, De Souza JV, Bethge L, Vonhoff S, Bronowska AK, Smietana M, Arseniyadis S
Publication type: Article
Publication status: Published
Journal: Journal of the American Chemical Society
Year: 2022
Volume: 2
Issue: 8
Pages: 1910-1917
Print publication date: 22/08/2022
Online publication date: 02/08/2022
Acceptance date: 22/07/2022
Date deposited: 07/10/2022
ISSN (print): 0002-7863
ISSN (electronic): 1520-5126
Publisher: American Chemical Society
URL: https://doi.org/10.1021/jacsau.2c00271
DOI: 10.1021/jacsau.2c00271
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