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Lookup NU author(s): Dr Elisa Anastasi
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2022 The Author(s). Published by Oxford University Press on behalf of Nucleic Acids Research.Cancer is a heterogeneous disease characterized by unregulated cell growth and promoted by mutations in cancer driver genes some of which encode suitable drug targets. Since the distinct set of cancer driver genes can vary between and within cancer types, evidence-based selection of drugs is crucial for targeted therapy following the precision medicine paradigm. However, many putative cancer driver genes can not be targeted directly, suggesting an indirect approach that considers alternative functionally related targets in the gene interaction network. Once potential drug targets have been identified, it is essential to consider all available drugs. Since tools that offer support for systematic discovery of drug repurposing candidates in oncology are lacking, we developed CADDIE, a web application integrating six human gene-gene and four drug-gene interaction databases, information regarding cancer driver genes, cancer-type specific mutation frequencies, gene expression information, genetically related diseases, and anticancer drugs. CADDIE offers access to various network algorithms for identifying drug targets and drug repurposing candidates. It guides users from the selection of seed genes to the identification of therapeutic targets or drug candidates, making network medicine algorithms accessible for clinical research. CADDIE is available at https://exbio.wzw.tum.de/caddie/ and programmatically via a python package at https://pypi.org/project/caddiepy/.
Author(s): Hartung M, Anastasi E, Mamdouh ZM, Nogales C, Schmidt HHHW, Baumbach J, Zolotareva O, List M
Publication type: Article
Publication status: Published
Journal: Nucleic Acids Research
Year: 2022
Volume: 50
Issue: W1
Pages: W138-W144
Print publication date: 05/07/2022
Online publication date: 17/05/2022
Acceptance date: 29/04/2022
Date deposited: 23/06/2023
ISSN (print): 0305-1048
ISSN (electronic): 1362-4962
Publisher: Oxford University Press
URL: https://doi.org/10.1093/nar/gkac384
DOI: 10.1093/nar/gkac384
PubMed id: 35580047
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