Toggle Main Menu Toggle Search

Open Access padlockePrints

Dietary patterns, genetic risk, and incidence of obesity: Application of reduced rank regression in 11,735 adults from the UK Biobank study

Lookup NU author(s): Dr Katherine Livingstone, Dr Carlos Celis Morales, Professor John Mathers

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Abstract

© 2022 Elsevier Inc. Few studies have derived dietary patterns based on intake of discretionary foods and beverages and examined associations with genetic risk and obesity. We examined associations between dietary patterns based on discretionary foods, saturated fatty acids (SFA), and fiber, with a polygenetic risk score (PRS) for obesity and risk of overall obesity, central obesity and high body fat (BF) up to 9.7 years later. Data from 11,735 adults from the UK Biobank cohort study were used. Dietary patterns were derived from 24-h dietary assessments using reduced rank regression (response variables: discretionary foods and beverages [%E]; SFA [%E]; fiber density [g/MJ]). Cox proportional hazard models were used to investigate associations between dietary patterns and incident overall obesity, central obesity and high BF, with interactions by PRS. Three dietary patterns (DP) were identified. DP1, correlated positively with discretionary foods and SFA, inversely with fiber, was associated with higher risk of central obesity (hazard ratio: 1.08; 95% confidence interval: 1.02, 1.14). DP2, correlated positively with discretionary foods and fiber, inversely with SFA, was not associated with obesity incidence. DP3, correlated positively with SFA and fiber, inversely with discretionary foods, was associated with lower risk of central obesity (hazard ratio: 0.92; 95% confidence interval: 0.87, 0.98). There was limited evidence of interactions with PRS. A dietary pattern high in high-SFA and low-fiber discretionary foods and beverages was associated with higher risk of obesity, independent of genetic predisposition.


Publication metadata

Author(s): Livingstone KM, Brayner B, Celis-Morales C, Ward J, Mathers JC, Bowe SJ

Publication type: Article

Publication status: Published

Journal: Preventive Medicine

Year: 2022

Volume: 158

Print publication date: 01/05/2022

Online publication date: 26/03/2022

Acceptance date: 21/03/2022

ISSN (print): 0091-7435

ISSN (electronic): 1096-0260

Publisher: Academic Press Inc.

URL: https://doi.org/10.1016/j.ypmed.2022.107035

DOI: 10.1016/j.ypmed.2022.107035

PubMed id: 35346749


Altmetrics

Altmetrics provided by Altmetric


Share