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EUS-guided choledochoduodenostomy with electrocautery-enhanced lumen-apposing metal stents in patients with malignant distal biliary obstruction: multicenter collaboration from the United Kingdom and Ireland

Lookup NU author(s): Professor John LeedsORCiD, Dr Manu Nayar, Professor Kofi Oppong

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Abstract

© 2021. Background and Aims: EUS-guided choledochoduodenostomy (EUS-CDD) with an electrocautery-enhanced lumen-apposing metal stent (EC-LAMS) has emerged as a viable method of establishing biliary drainage in patients with malignant distal biliary obstruction (MDBO). Our aim was to assess the efficacy, safety, and outcomes in patients with MDBO who underwent EUS-CDD with an EC-LAMS. Methods: A retrospective review of consecutive patients with MDBO who underwent EUS-CDD with EC-LAMSs at 8 tertiary institutions across the United Kingdom and Ireland between September 2016 and November 2020 was undertaken. Results: One hundred twenty patients (55% men) with a median age of 73 years (interquartile range, 17; range, 43-94) were included. The median follow-up period in 117 patients was 70 days (interquartile range, 169; range, 3-869), and 23 patients (19.2%) were alive at the end of the follow-up. Three patients were lost to follow-up. Technical success was achieved in 109 patients (90.8%). Clinical success (reduction of serum bilirubin to ≤50% of original value within 14 days) was achieved in 94.8% of patients (92/97). The adverse event rate was 17.5% (n = 21). Biliary reintervention after initial technical success was required in 9 patients (8.3%). Conclusions: EUS-CDD with EC-LAMSs at tertiary institutions within a regional hepatopancreatobiliary network for treatment of MDBO was effective in those where ERCP was not possible or was unsuccessful. When technical failures or adverse events occur, most patients can be managed with conservative or endoscopic therapy.

Publication metadata

Author(s): On W, Paranandi B, Smith AM, Venkatachalapathy SV, James MW, Aithal GP, Varbobitis I, Cheriyan D, McDonald C, Leeds JS, Nayar MK, Oppong KW, Geraghty J, Devlin J, Ahmed W, Scott R, Wong T, Huggett MT

Publication type: Article

Publication status: Published

Journal: Gastrointestinal Endoscopy

Year: 2022

Volume: 95

Issue: 3

Pages: 432-442

Print publication date: 01/03/2022

Online publication date: 09/10/2021

Acceptance date: 27/09/2021

ISSN (print): 0016-5107

ISSN (electronic): 1097-6779

Publisher: Elsevier Inc.

URL: https://doi.org/10.1016/j.gie.2021.09.040

DOI: 10.1016/j.gie.2021.09.040

PubMed id: 34637805

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