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The production of hydrogen peroxide during early-stage protein aggregation: a common pathological mechanism in different neurodegenerative diseases?

Lookup NU author(s): Dr Matthew GermanORCiD

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Abstract

By means of an ESR spin-trapping method, we have shown that Ab (amyloid b), a-synuclein and various toxic forms of the prion protein all appear to generate H₂O₂ in vitro. A fundamental molecular mechanism underlying the pathogenesis of cell death in several different neurodegenerative diseases could be the direct production of H₂O₂ during the early stages of protein aggregation.

Publication metadata

Author(s): Tabner BJ, Turnbull S, Fullwood N, German MJ, Allsop D

Publication type: Article

Publication status: Published

Journal: Biochemical Society Transactions

Year: 2005

Volume: 33

Issue: 4

Pages: 548-550

ISSN (print): 0300-5127

ISSN (electronic): 1470-8752

Publisher: Portland Press Ltd.

URL: http://dx.doi.org/10.1042/BST0330548

DOI: 10.1042/BST0330548

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