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Lookup NU author(s): Prisca Wibowo, Dr Sarah Charman, Dr Nduka Okwose, Dr Kieren Hollingsworth, Dr Guy MacGowanORCiD, Professor Djordje JakovljevicORCiD
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).
Decline in cardiac high-energy phosphate metabolism [phosphocreatine-to-ATP (PCr/ATP) ratio] and whole body metabolism increase the risk of heart failure and metabolic diseases. The aim of the present study was to assess the relationship between PCr/ATP ratio and measures of body metabolic function. A total of 35 healthy women (56+/-14.0 years of age) underwent cardiac 31P magnetic resonance spectroscopy to assess PCr/ATP ratio - an index of cardiac high-energy phosphate metabolism. Fasting and 2-hour glucose levels were assessed using oral glucose tolerance test. Indirect calorimetry was performed to determine oxygen consumption and resting metabolic rate. There were no significant relationships between PCr/ATP ratio and resting metabolic rate (r=-0.09, p=0.62), oxygen consumption (r=-0.11, p=0.54), fasting glucose levels (r=-0.31, p=0.07), and 2-hour plasma glucose (r=-0.10, p=0.58). Adjusted analysis for covariates including age, body mass index, fat mass, and physical activity, had no significant influence on the relationship between PCr/ATP ratio and body metabolism. In conclusion, the lack of relationship between cardiac PCr/ATP ratio, glucose control and metabolic rate may suggest that overall metabolic function does not influence cardiac high-energy phosphate metabolism.
Author(s): Wibowo PG, Charman SJ, Okwose NC, Velicki L, Popovic D, Hollingsworth KG, Macgowan GA, Jakovljevic DG
Publication type: Article
Publication status: Published
Journal: Physiological Research
Year: 2021
Volume: 70
Issue: 3
Pages: 393-399
Print publication date: 01/06/2021
Online publication date: 12/05/2021
Acceptance date: 18/03/2021
Date deposited: 24/08/2021
ISSN (print): 0862-8408
ISSN (electronic): 1802-9973
Publisher: Akademie Ved Ceske Republiky; Fyziologicky Ustav
URL: https://doi.org/10.33549/physiolres.934627
DOI: 10.33549/physiolres.934627
PubMed id: 33982584
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