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Lookup NU author(s): Dr Ben Shillitoe, Professor Mary Slatter, Professor Andrew GenneryORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2021, The Author(s). Since the first clinical description in 1952, immunoglobulin replacement therapy remains the mainstay of treatment of patients with X-linked agammaglobulinemia (XLA). However, this therapy only replaces IgG isotype and does not compensate for the loss of Bruton tyrosine kinase in non-B-lymphocytes. Patients may still therefore develop complications despite current standard of care. Here, we describe an XLA patient with persistent chronic norovirus infection, refractory to treatment and causing intestinal failure. The patient underwent haematopoietic stem cell transplantation, curing XLA and allowed clearance of norovirus prior to humoral immunoreconstitution, suggesting non-humoral immunodeficiency in these patients.
Author(s): Shillitoe BMJ, Ponsford M, Slatter MA, Evans J, Struik S, Cosgrove M, Doull I, Jolles S, Gennery AR
Publication type: Article
Publication status: Published
Journal: Journal of Clinical Immunology
Year: 2021
Volume: 41
Pages: 1574-1581
Print publication date: 01/10/2021
Online publication date: 23/06/2021
Acceptance date: 14/06/2021
Date deposited: 08/07/2021
ISSN (print): 0271-9142
ISSN (electronic): 1573-2592
Publisher: Springer Nature
URL: https://doi.org/10.1007/s10875-021-01088-2
DOI: 10.1007/s10875-021-01088-2
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