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Variability in the control of cell division underlies sepal epidermal patterning in Arabidopsis thaliana

Lookup NU author(s): Professor Boguslaw ObaraORCiD

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Abstract

How growth and proliferation are precisely controlled in organs during development and how the regulation of cell division contributes to the formation of complex cell type patterns are important questions in developmental biology. Such a pattern of diverse cell sizes is characteristic of the sepals, the outermost floral organs, of the plant Arabidopsis thaliana. To determine how the cell size pattern is formed in the sepal epidermis, we iterate between generating predictions from a computational model and testing these predictions through time-lapse imaging. We show that the cell size diversity is due to the variability in decisions of individual cells about when to divide and when to stop dividing and enter the specialized endoreduplication cell cycle. We further show that altering the activity of cell cycle inhibitors biases the timing and changes the cell size pattern as our model predicts. Models and observations together demonstrate that variability in the time of cell division is a major determinant in the formation of a characteristic pattern. © 2010 Roeder et al.

Publication metadata

Author(s): Roeder AHK, Chickarmane V, Cunha A, Obara B, Manjunath BS, Meyerowitz EM

Publication type: Article

Publication status: Published

Journal: PLoS Biology

Year: 2010

Volume: 8

Issue: 5

Online publication date: 11/05/2010

Date deposited: 07/05/2021

ISSN (print): 1544-9173

ISSN (electronic): 1545-7885

Publisher: Public Library of Science

URL: https://doi.org/10.1371/journal.pbio.1000367

DOI: 10.1371/journal.pbio.1000367

PubMed id: 20485493

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