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Lookup NU author(s): Professor Sanjay PandanaboyanaORCiD
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© 2015 Steunstichting ESOT.Transplantation of organs from donors with malignancy poses clinical and ethical questions regarding outcome, informed consent, immunosuppression and follow-up. We review our experience of kidney and liver transplantation from such donors. Our database was complemented by data from National Health Service Blood and Transplant. All patients who received a renal or liver transplant in our institution between April 2003 and January 2014 were included. About 2546 liver and kidney transplants were performed: 71 recipients received 53 kidney and 18 liver transplants. These included 51 (36 kidney, 15 liver) CNS malignancy, and six kidneys, three ipsilateral and three contralateral with RCC. One kidney recipient developed donor-transmitted lung cancer in the transplant kidney, and one liver transplant recipient developed donor-transmitted lymphoma; both subsequently died. Seven recipients developed donor-unrelated cancer. No recipient developed cancer, whereas the donor had a CNS or RCC. The 1-, 3- and 5-year patient survival was 96%, 93.3% and 75%, respectively, for kidneys and 83.3%, 75% and 50%, respectively, for liver. Where donor malignancy was known and assessed before transplantation, judicious use of kidney and liver for transplant achieved satisfactory outcome. The risk of transmission from donors with CNS and low-grade renal malignancy remains extremely low.
Author(s): Pandanaboyana S, Longbotham D, Hostert L, Attia M, Baker R, Menon K, Ahmad N
Publication type: Article
Publication status: Published
Journal: Transplant International
Year: 2016
Volume: 29
Issue: 1
Pages: 73-80
Print publication date: 05/01/2016
Online publication date: 24/09/2015
Acceptance date: 18/09/2015
ISSN (print): 0934-0874
ISSN (electronic): 1432-2277
Publisher: Blackwell Publishing Ltd
URL: https://doi.org/10.1111/tri.12693
DOI: 10.1111/tri.12693
PubMed id: 26402442
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