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Lookup NU author(s): Professor Sanjay PandanaboyanaORCiD
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© The Author(s) 2018.Nonocclusive mesenteric ischemia (NOMI) is a condition that can encompass ischemia, inflammation, and infarction of the intestinal wall. In contrast to most patients with acute mesenteric ischemia, NOMI is distinguished by patent arteries and veins. The clinical presentation of NOMI is often insidious and nonspecific, resulting in a delayed diagnosis. Patients most at risk are those with severe acute and critical disease, including major surgery and trauma. Nonocclusive mesenteric ischemia is part of a spectrum, from mild, asymptomatic, and an unexpected finding on CT scanning, through to those exhibiting abdominal distension and peritonitis. Severe NOMI is associated with a significant mortality rate. This review of NOMI pathophysiology was conducted to document current concepts and evidence, to examine the implications for diagnosis and treatment, and to identify gaps in knowledge that might direct future research. The key pathologic mechanisms involved in the genesis of NOMI represent an exaggerated normal physiological response to maintain perfusion of vital organs at the expense of mesenteric perfusion. A supply–demand mismatch develops in the intestine due to the development of persistent mesenteric vasoconstriction resulting in reduced blood flow and oxygen delivery to the intestine, particularly to the vulnerable superficial mucosa. This mismatch can be exacerbated by raised intra-abdominal pressure, enteral nutrition, and the use of certain vasoactive drugs, ultimately resulting in the development of intestinal ischemia. Strategies for prevention, early detection, and treatment are urgently needed.
Author(s): Al-Diery H, Phillips A, Evennett N, Pandanaboyana S, Gilham M, Windsor JA
Publication type: Review
Publication status: Published
Journal: Journal of Intensive Care Medicine
Year: 2019
Volume: 34
Issue: 10
Pages: 771-781
Print publication date: 01/10/2019
Online publication date: 23/07/2018
Acceptance date: 02/04/2016
ISSN (print): 0885-0666
ISSN (electronic): 1525-1489
Publisher: SAGE Publications Inc.
URL: https://doi.org/10.1177/0885066618788827
DOI: 10.1177/0885066618788827
PubMed id: 30037271
