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Lookup NU author(s): Dr Michael FirbankORCiD, Professor John O'Brien
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
BACKGROUND & AIMS: Consensus is lacking on whether light to moderate consumption of alcohol compared to abstinence is neuroprotective. In this study, we investigated the relationship between self-reported alcohol use and brain volume change over 2 years in middle aged subjects. METHODS: A sample of 162 subjects (aged 40-59 at baseline) from the PREVENT-Dementia programme underwent MRI scans on two separate occasions (mean interval 734 days; SD 42 days). We measured longitudinal rates of brain atrophy using the FSL Siena toolbox, and change in hippocampus volume from segmentation in SPM. RESULTS: Controlling for age and sex, there were no significant associations of either total brain, ventricular, or hippocampus volume change with alcohol consumption. Adjusting for lifestyle, demographic and vascular risk factors did not alter this. CONCLUSIONS: We did not find any evidence of influence of alcohol consumption on changes in brain volume over a 2 year period in 40-60 year olds.
Author(s): Firbank MJ, O'Brien JT, Ritchie K, Wells K, Williams GW, Su L, Ritchie CW
Publication type: Article
Publication status: Published
Journal: Journal of Neurology
Year: 2020
Volume: 267
Pages: 3282-3286
Print publication date: 01/11/2020
Online publication date: 20/06/2020
Acceptance date: 12/06/2020
Date deposited: 11/06/2020
ISSN (print): 0340-5354
ISSN (electronic): 1432-1459
Publisher: Springer Medizin
URL: https://doi.org/10.1007/s00415-020-10000-8
DOI: 10.1007/s00415-020-10000-8
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