Browse by author
Lookup NU author(s): Dr Sergey MelnikovORCiD
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
© 2019 by the authors. Licensee MDPI, Basel, Switzerland.In the past two decades, tRNA molecules and their corresponding aminoacyl-tRNA synthetases (aaRS) have been extensively used in synthetic biology to genetically encode post-translationally modified and unnatural amino acids. In this review, we briefly examine one fundamental requirement for the successful application of tRNA/aaRS pairs for expanding the genetic code. This requirement is known as “orthogonality”—the ability of a tRNA and its corresponding aaRS to interact exclusively with each other and avoid cross-reactions with additional types of tRNAs and aaRSs in a given organism.
Author(s): Melnikov SV, Soll D
Publication type: Review
Publication status: Published
Journal: International Journal of Molecular Sciences
Year: 2019
Volume: 20
Issue: 8
Pages: 1929
Online publication date: 19/04/2020
Acceptance date: 17/04/2020
ISSN (print): 1661-6596
ISSN (electronic): 1422-0067
Publisher: MDPI AG
URL: https://doi.org/10.3390/ijms20081929
DOI: 10.3390/ijms20081929
PubMed id: 31010123