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Lookup NU author(s): Dr Sergey MelnikovORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2015 Macmillan Publishers Limited. All rights reserved.Eukaryotic ribosomal proteins, unlike their bacterial homologues, possess nuclear localization signals (NLSs) to enter the cell nucleus during ribosome assembly. Here we provide a comprehensive comparison of bacterial and eukaryotic ribosomes to show that NLSs appear in conserved ribosomal proteins via remodelling of their RNA-binding domains. This finding enabled us to identify previously unknown NLSs in ribosomal proteins from humans, and suggests that, apart from promoting protein transport, NLSs may facilitate folding of ribosomal RNA.
Author(s): Melnikov S, Ben-Shem A, Yusupova G, Yusupov M
Publication type: Article
Publication status: Published
Journal: Nature Communications
Year: 2015
Volume: 6
Online publication date: 11/06/2015
Acceptance date: 30/04/2015
Date deposited: 27/05/2020
ISSN (electronic): 2041-1723
Publisher: Nature Publishing Group
URL: https://doi.org/10.1038/ncomms8382
DOI: 10.1038/ncomms8382
PubMed id: 26066547
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