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Lookup NU author(s): Dr Sergey MelnikovORCiD
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© 2015 Nature America, Inc. All rights reserved.We report crystal structures of the Thermus thermophilus ribosome at 2.3- to 2.5-Å resolution, which have enabled modeling of rRNA modifications. The structures reveal contacts of modified nucleotides with mRNA and tRNAs or protein pY, and contacts within the ribosome interior stabilizing the functional fold of rRNA. Our work provides a resource to explore the roles of rRNA modifications and yields a more comprehensive atomic model of a bacterial ribosome.
Author(s): Polikanov YS, Melnikov SV, Soll D, Steitz TA
Publication type: Article
Publication status: Published
Journal: Nature Structural and Molecular Biology
Year: 2015
Volume: 22
Issue: 4
Pages: 342-344
Print publication date: 01/04/2015
Online publication date: 16/03/2015
Acceptance date: 17/02/2015
ISSN (print): 1545-9993
ISSN (electronic): 1545-9985
Publisher: Nature Publishing Group
URL: https://doi.org/10.1038/nsmb.2992
DOI: 10.1038/nsmb.2992
PubMed id: 25775268
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