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The effect of periodontal scaling and root polishing on serum IL-17E concentrations and the IL-17A:IL-17E ratio

Lookup NU author(s): Dr Christopher NileORCiD

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Abstract

© 2016, Springer-Verlag Berlin Heidelberg.Objectives: The serum IL-17A:IL-17E ratio has previously been demonstrated to be a clinical marker of periodontitis. The aim of this study was to determine the effects of non-surgical periodontal treatment on the serum IL-17A:IL-17E ratio. Materials and methods: Forty chronic periodontitis patients completed this study and received periodontal treatment comprising scaling and root planing plus ultrasonic debridement. Clinical data were recorded at baseline, 6 weeks (R1) after treatment completion (full-mouth or quadrant-scaling and root planing) and 25 weeks after baseline (R2). Serum samples were taken at each time point and cytokines concentrations determined by ELISA. Results: Following treatment, statistically significant reductions were noted in clinical parameters. However, IL-17A and IL-17E concentrations were significantly greater than baseline values before- and after-adjusting for smoking. The IL-17A:IL-17E ratio was lower at R1 and R2. Serum IL-6 and TNF levels were significantly lower at R1 only. Also exclusively at R1, serum IL-17A and IL-17E correlated positively with clinical parameters, while the IL-17A:IL-17E ratio correlated negatively with probing pocket depth and clinical attachment. Conclusion: Increased serum IL-17E and a reduced IL-17A:IL-17E ratio may be indicative and/or a consequence of periodontal therapy. Therefore, the role of IL-17E in periodontal disease progression and the healing process is worthy of further investigation. Clinical relevance: IL-17E may be a valuable biomarker to monitor the healing process following periodontal treatment as increased IL-17E levels and a reduced IL-17A:IL-17E ratio could reflect clinical improvements post-therapy. Therefore, monitoring serum IL-17E might be useful to identify individuals who require additional periodontal treatment.

Publication metadata

Author(s): Nile CJ, Apatzidou DA, Awang RA, Riggio MP, Kinane DF, Lappin DF

Publication type: Article

Publication status: Published

Journal: Clinical Oral Investigations

Year: 2016

Volume: 20

Issue: 9

Pages: 2529-2537

Online publication date: 18/02/2016

Acceptance date: 10/02/2016

ISSN (print): 1432-6981

ISSN (electronic): 1436-3771

Publisher: Springer Verlag

URL: https://doi.org/10.1007/s00784-016-1749-8

DOI: 10.1007/s00784-016-1749-8

PubMed id: 26888221

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