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The application of phenotypic microarray analysis to anti-fungal drug development

Lookup NU author(s): Dr Christopher NileORCiD

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Abstract

© 2017 Elsevier B.V.Candida albicans metabolic activity in the presence and absence of acetylcholine was measured using phenotypic microarray analysis. Acetylcholine inhibited C. albicans biofilm formation by slowing metabolism independent of biofilm forming capabilities. Phenotypic microarray analysis can therefore be used for screening compound libraries for novel anti-fungal drugs and measuring antifungal resistance.

Publication metadata

Author(s): Greetham D, Lappin DF, Rajendran R, O'Donnell L, Sherry L, Ramage G, Nile C

Publication type: Article

Publication status: Published

Journal: Journal of Microbiological Methods

Year: 2017

Volume: 134

Pages: 35-37

Print publication date: 01/03/2017

Online publication date: 09/01/2017

Acceptance date: 06/01/2017

Date deposited: 24/02/2020

ISSN (print): 0167-7012

ISSN (electronic): 1872-8359

Publisher: Elsevier B.V.

URL: https://doi.org/10.1016/j.mimet.2017.01.004

DOI: 10.1016/j.mimet.2017.01.004

PubMed id: 28082175

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