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Lookup NU author(s): Professor Akane Kawamura
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).
© 2015 A Kawamura.The response to hypoxia is primarily mediated by the hypoxia-inducible transcription factor (HIF). Levels of HIF are regulated by the oxygen-sensing HIF hydroxylases, members of the 2-oxoglutarate (2OG) dependent oxygenase family. JmjC-domain containing histone lysine demethylases (JmjC-KDMs), also members of the 2OG oxygenase family, are key epigenetic regulators that modulate the methylation levels of histone tails. Kinetic studies of the JmjC-KDMs indicate they could also act in an oxygen-sensitive manner. This may have important implications for epigenetic regulation in hypoxia. In this review we examine evidence that the levels and activity of JmjC-KDMs are sensitive to oxygen availability, and consider how this may influence their roles in early development and hypoxic disease states including cancer and cardiovascular disease.
Author(s): Hancock RL, Dunne K, Walport LJ, Flashman E, Kawamura A
Publication type: Review
Publication status: Published
Journal: Epigenomics
Year: 2015
Volume: 7
Issue: 5
Pages: 791-811
Print publication date: 01/08/2015
Online publication date: 02/04/2015
Acceptance date: 01/01/1900
ISSN (print): 1750-1911
ISSN (electronic): 1750-192X
Publisher: Future Medicine Ltd.
URL: https://doi.org/10.2217/epi.15.24
DOI: 10.2217/epi.15.24
PubMed id: 25832587
