Synthesis and characterization of genipin-crosslinked chitosan hydrogels

Stanojevic, A; Vukajlovic, Dj; Parker, J; Novakovic, K

Synthesis and characterization of genipin-crosslinked chitosan hydrogels

Lookup NU author(s): Dr Ana Stanojevic, Đurđa Vukajlović, Dr Julie Parker, Professor Katarina Novakovic ORCiD

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Abstract

Chitosan-based hydrogels were synthesized by crosslinking with genipin. Genipin, a naturally derived agent, was selected because of the lower cytotoxicity compared to many other commonly used synthetic crosslinking reagents. Swelling properties of these hydrogels were studied in solutions of different pH’s. Fourier transform infrared spectroscopy was used to determine the functional groups present in the gel constituents together with understanding as to how the spectra change upon swelling or shrinking. Thermal characteristics were examined using differential scanning calorimetry. The results were used to evaluate the possibility for applications of genipin-crosslinked chitosan hydrogels in tissue engineering and drug delivery.