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Lookup NU author(s): Dr Bridget Griffiths, Dr James Miller
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© The Author(s) 2018. Objectives. The aim was to identify and characterize all incident adult cases of idiopathic inflammatory myopathies (IIM) between 1 January 2007 and 31 December 2016 in the City of Salford, UK. Methods. Adults first diagnosed with IIM within the study period were identified by: a Salford Royal NHS Foundation Trust (SRFT) inpatient episode IIM-specific ICD-10 coding search; all new patient appointments to SRFT neuromuscular outpatient clinics; and all Salford residents enrolled within the UKMYONET study. All patients with definite IIM by the 2017 EULAR/ACR classification criteria were included, as were probable cases if consensus expert opinion agreed. Cases were excluded if < 18 years of age at disease onset, if they did not meet probable criteria or when probable but expert opinion concluded a non-IIM diagnosis. Results. The multimodal case ascertainment identified 1156 cases which, after review and application of exclusion criteria, resulted in 32 incident cases during the study period. Twenty-three of 32 were female, with a mean age of 58.1 years. The mean incidence of adult IIM was 17.6/1 000 000 person years, and higher for females than for males (25.2 vs 10.0/1 000 000 person years, respectively). A significant incidence increase over time was apparent (13.6 vs 21.4/1 000 000 person years; P=0.032). Using EULAR/ACR classification criteria, the largest IIM subtype (21/32) was PM, followed by DM (8/32), IBM (2/32) and amyopathic DM (1/32). Expert opinion subtype differed from EULAR/ACR classification criteria in 19/32 cases. Conclusion. The incidence of adult IIM in Salford is 17.6/1 000 000 person years, higher in females, and is increasing over time. Disagreement exists between EULAR/ACR-derived and expert opinionderived IIM subtype assignments.
Author(s): Parker MJS, Oldroyd A, Roberts ME, Ollier WE, New RP, Cooper RG, Chinoy H, Ahmed Y, Armstrong R, Bernstein R, Black C, Bowman S, Bruce I, Butler R, Carty J, Chattopadhyay C, Chelliah E, Clarke F, Dawes P, Devlin J, Edwards C, Emery P, Fordham J, Fraser A, Gaston H, Gordon P, Griffiths B, Gunawardena H, Hall F, Harrison B, Hay E, Horden L, Isaacs J, Jones A, Kamath S, Kennedy T, Kitas G, Klimiuk P, Knights S, Lambert J, Lanyon P, Laxminarayan R, Lecky B, Luqmani R, Marks J, Martin M, McGonagle D, McHugh N, McKenna F, McLaren J, McMahon M, McRorie E, Merry P, Miles S, Miller J, Nicholls A, Nixon J, Ong V, Over K, Packham J, Pipitone N, Plant M, Pountain G, Pullar T, Sanders P, Scott D, Scott D, Shadforth M, Sheeran T, Srinivasan A, Swinson D, Teh L-S, Webley M, Williams B, Winer J
Publication type: Article
Publication status: Published
Journal: Rheumatology Advances in Practice
Year: 2018
Volume: 2
Issue: 2
Pages: 1-7
Online publication date: 17/09/2018
Acceptance date: 02/08/2018
Date deposited: 03/04/2019
ISSN (electronic): 2514-1775
Publisher: Oxford University Press
URL: https://doi.org/10.1093/rap/rky035
DOI: 10.1093/rap/rky035
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