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Prevalence of Medication Nonadherence to co-medication Compared to immunosuppressants in Heart Transplant Recipients: Findings From the International Cross-sectional BRIGHT Study

Lookup NU author(s): Dr Gareth Parry

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Abstract

© 2018 Purpose: To assess and compare the prevalence of medication nonadherence (MNA) (implementation and persistence) to immunosuppressants and co-medications in heart transplant recipients. Methods: MNA prevalence was assessed using the Basel Assessment of Adherence to Immunosuppressive Medications Scale (self-report) and compared using logistic regression in a 4-continent sample of 1397 heart transplant recipients from 36 heart transplant centers in 11 countries. Findings: MNA was significantly (α = 0.05) higher to co-medications than to immunosuppressants (taking nonadherence: 23.9% vs 17.3%; odds ratio [OR] = 1.5; 95% CI, 1.30–1.73; drug holiday: 5.7% vs 1.9%; OR = 3.17; 95% CI, 2.13–4.73; dose alteration: 3.8% vs 1.6%; OR = 2.46; 95% CI, 1.49–4.06; and discontinuation: 2.6% vs 0.5%; OR = 5.15; 95% CI, 2.36–11.20). Implications: The observed MNA necessitates adherence-enhancing interventions encompassing the entire post–heart transplant medication regimen. ClinicalTrials.gov identifier: NCT01608477.

Publication metadata

Author(s): Helmy R, Scalso de Almeida S, Denhaerynck K, Berben L, Dobbels F, Russell CL, de Aguiar Roza B, De Geest S, Crespo-Leiro MG, Cupples S, De Simone P, Groenewoud A, Kugler C, Ohler L, Van Cleemput J, Poncelet AJ, Sebbag L, Michel M, Bernard A, Doesch A, Livi U, Potena L, Brossa-Loidi V, Segovia-Cubero J, Almenar-Bonet L, Saint-Gerons CS, Mohacsi P, Horvath E, Riotto C, Parry G, Firouzi A, Kozuszko S, Haddad H, Kaan A, Fisher G, Miller T, Flattery M, Ludrosky K, Albert N, Coleman B, Trammell J, Epstein F, St Clair K, Kao A, Molina M, Canales KR, Ayoub AC, Barone F, Harkess M, Maddicks-Law J

Publication type: Article

Publication status: Published

Journal: Clinical Therapeutics

Year: 2019

Volume: 41

Issue: 1

Pages: 130-136

Print publication date: 01/01/2019

Online publication date: 24/12/2018

Acceptance date: 12/11/2015

ISSN (print): 0149-2918

ISSN (electronic): 1879-114X

Publisher: Elsevier Inc.

URL: https://doi.org/10.1016/j.clinthera.2018.11.007

DOI: 10.1016/j.clinthera.2018.11.007

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