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Lookup NU author(s): Professor Ann DalyORCiD
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© 2018 American Chemical Society. The HLA class I allele HLA-A∗33:03 is a risk factor for ticlopidine-induced liver injury. Herein, we show HLA class I-restricted ticlopidine-specific CD8+ T-cell activation in healthy donors expressing HLA-A∗33:03. Cloned CD8+ T-cells proliferated and secreted IFN-γ in the presence of ticlopidine and autologous antigen presenting cells. A reduction of the T-cell response after blocking with HLA-class I and HLA-A∗33 antibodies indicates that the interaction between drugs and the HLA allele detected in genetic association studies may be important for T-cell activation.
Author(s): Usui T, Tailor A, Faulkner L, Meng X, Farrell J, Daly AK, Dear GJ, Park BK, Naisbitt DJ
Publication type: Article
Publication status: Published
Journal: Chemical Research in Toxicology
Year: 2018
Volume: 31
Issue: 10
Pages: 1022-1024
Print publication date: 15/10/2018
Online publication date: 04/09/2018
Acceptance date: 02/04/2018
ISSN (print): 0893-228X
ISSN (electronic): 1520-5010
Publisher: American Chemical Society
URL: https://doi.org/10.1021/acs.chemrestox.8b00163
DOI: 10.1021/acs.chemrestox.8b00163
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