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Heart transplantation survival and sex-related differences

Lookup NU author(s): Dr Gareth Parry

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Abstract

© 2018, Springer International Publishing AG, part of Springer Nature. Orthotopic heart transplantation (OHT) is the “gold standard” treatment for patients with end-stage heart failure, with approximately 5000 transplants performed each year worldwide. Heart transplantation survival rates have progressively improved at all time points, despite an increase in donor and recipient age and comorbidity and greater recipient urgency; according to the registry of the International Society of Heart and Lung Transplantation (ISHLT), the median survival of patients posttransplantation is currently 12.2 years. Long-term survival is sub-optimal, and outcomes after OHT remain constrained by the development of acute rejection and cardiac allograft vasculopathy (CAV). Moreover, donor organs are in short supply, making optimal organ utilization an ongoing priority. For these reasons, substantial interest continues to exist in identifying factors portending increased survival and improved organ utilization.


Publication metadata

Author(s): Previato M, Osto E, Kerkhof PLM, Parry G, Tona F

Publication type: Book Chapter

Publication status: Published

Book Title: Sex-Specific Analysis of Cardiovascular Function

Year: 2018

Volume: 1065

Pages: 379-388

Online publication date: 27/07/2018

Acceptance date: 02/04/2018

Series Title: Advances in Experimental Medicine and Biology

Publisher: Springer

Place Published: New York

URL: https://doi.org/10.1007/978-3-319-77932-4_24

DOI: 10.1007/978-3-319-77932-4_24

Library holdings: Search Newcastle University Library for this item

ISBN: 9783319779317


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