Epigenetics in Liver Disease: Involvement of Oxidative Stress

Mann, J

doi:10.1016/B978-0-12-804274-8.00015-1

Epigenetics in Liver Disease: Involvement of Oxidative Stress

Lookup NU author(s): Professor Jelena Mann

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Abstract

© 2017 Elsevier Inc. All rights reserved. Chronic liver disease (CLD) is one of the major causes of death that has a year-on-year rising incidence and in the United Kingdom is now the fifth leading cause of early loss of life. The rise in deaths caused by CLD is in contrast to other major causes of death, which have been declining (. Friedman, 2008a,b). Major causes of CLD are alcohol abuse, obesity/metabolic disease, autoimmune hepatitis, and viral hepatitis (HBV and HCV); furthermore, the majority of people dying from CLD are under the age of 70. Although there are now highly effective treatments for HCV, by contrast there are no effective treatments for alcoholic and nonalcoholic fatty liver diseases (ALD and NAFLD), which represent the majority causes of CLD in the developed/Western world. Oxidative stress plays a major role in the pathogenesis of both ALD and NAFLD (. Zima et al., 2001; Vidali et al., 2008; Sid et al., 2013; Ignatowicz et al., 2013; Fernandez-Checa, 2003; Albano, 2006).