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Binocular response modulation in the lateral geniculate nucleus

Lookup NU author(s): Professor Michael SchmidORCiD

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Abstract

© 2018 Wiley Periodicals, Inc. The dorsal lateral geniculate nucleus of the thalamus (LGN) receives the main outputs of both eyes and relays those signals to the visual cortex. Each retina projects to separate layers of the LGN so that each LGN neuron is innervated by a single eye. In line with this anatomical separation, visual responses of almost all of LGN neurons are driven by one eye only. Nonetheless, many LGN neurons are sensitive to what is shown to the other eye as their visual responses differ when both eyes are stimulated compared to when the driving eye is stimulated in isolation. This, predominantly suppressive, binocular modulation of LGN responses might suggest that the LGN is the first location in the primary visual pathway where the outputs from the two eyes interact. Indeed, the LGN features several anatomical structures that would allow for LGN neurons responding to one eye to modulate neurons that respond to the other eye. However, it is also possible that binocular response modulation in the LGN arises indirectly as the LGN also receives input from binocular visual structures. Here we review the extant literature on the effects of binocular stimulation on LGN spiking responses, highlighting findings from cats and primates, and evaluate the neural circuits that might mediate binocular response modulation in the LGN.


Publication metadata

Author(s): Dougherty K, Schmid MC, Maier A

Publication type: Article

Publication status: Published

Journal: Journal of Comparative Neurology

Year: 2019

Volume: 527

Issue: 3

Pages: 522-534

Print publication date: 15/02/2019

Online publication date: 09/03/2018

Acceptance date: 06/02/2018

ISSN (print): 0021-9967

ISSN (electronic): 1096-9861

Publisher: Wiley-Liss Inc.

URL: https://doi.org/10.1002/cne.24417

DOI: 10.1002/cne.24417

PubMed id: 29473163


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