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Evaluating Sex and Age Differences in ADI-R and ADOS Scores in a Large European Multi-site Sample of Individuals with Autism Spectrum Disorder

Lookup NU author(s): Emerita Professor Helen McConachie

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).

Abstract

© 2018 The Author(s) Research on sex-related differences in Autism Spectrum Disorder (ASD) has been impeded by small samples. We pooled 28 datasets from 18 sites across nine European countries to examine sex differences in the ASD phenotype on the ADI-R (376 females, 1763 males) and ADOS (233 females, 1187 males). On the ADI-R, early childhood restricted and repetitive behaviours were lower in females than males, alongside comparable levels of social interaction and communication difficulties in females and males. Current ADI-R and ADOS scores showed no sex differences for ASD severity. There were lower socio-communicative symptoms in older compared to younger individuals. This large European ASD sample adds to the literature on sex and age variations of ASD symptomatology.

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Author(s): Tillmann J, Ashwood K, Absoud M, Bolte S, Bonnet-Brilhault F, Buitelaar JK, Calderoni S, Calvo R, Canal-Bedia R, Canitano R, de Bildt A, Gomot M, Hoekstra PJ, Kaale A, McConachie H, Murphy DG, Narzisi A, Oosterling I, Pejovic-Milovancevic M, Persico AM, Puig O, Roeyers H, Rommelse N, Sacco R, Scandurra V, Stanfield AC, Zander E, Charman T

Publication type: Article

Publication status: Published

Journal: Journal of Autism and Developmental Disorders

Year: 2018

Volume: 48

Issue: 7

Pages: 2490-2505

Print publication date: 01/07/2018

Online publication date: 21/02/2018

Acceptance date: 02/04/2016

Date deposited: 05/03/2018

ISSN (print): 0162-3257

ISSN (electronic): 1573-3432

Publisher: Springer New York LLC

URL: https://doi.org/10.1007/s10803-018-3510-4

DOI: 10.1007/s10803-018-3510-4

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