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An epistemology of patient safety research: a framework for study design and interpretation. Part 4. One size does not fit all

Lookup NU author(s): Emeritus Professor Richard Thomson

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Abstract

This is the final article in the series on the epistemology of patient safety research, and considers the selection of study design and end points during the planning of an evaluation. The key message of this series is that "one size does not fit all": the nature of the evaluation will depend on logistical and pragmatic constraints, a priori assessment of the probability of benefits and harms, the plausible scale of these effects and the target audience for the results. This paper also discusses the advantages of mixed method designs. The strength of any conclusions can be increased if different end points concur and the authors therefore advocate assessment of the effect of the intervention on different end points across the generic causal chain linking structure, process and outcome. The use of both qualitative and quantitative methods is also advocated to help explain findings, generate theory and help contextualise results. We show how a bayesian framework can be used to synthesise evidence from a number of different sources and why this approach may be particularly appropriate for the evaluation of patient safety interventions.


Publication metadata

Author(s): Brown C, Hofer T, Johal A, Thomson R, Nicholl J, Franklin BD, Lilford RJ

Publication type: Article

Publication status: Published

Journal: Quality and Safety in Health Care

Year: 2008

Volume: 17

Issue: 3

Pages: 178-181

ISSN (print): 1475-3898

ISSN (electronic): 1475-3901

Publisher: BMJ Group

URL: http://dx.doi.org/10.1136/qshc.2007.023663

DOI: 10.1136/qshc.2007.023663


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