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Health-related quality of life of children on treatment for acute lymphoblastic leukemia: A systematic review.

Lookup NU author(s): Dr Marion Mateos

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Abstract

Children with acute lymphoblastic leukemia (ALL) undergo intense anticancer treatment. We systematically reviewed 22 studies evaluating 2,073 ALL patients’ health-related quality of life (HRQL) and its clinical/demographic correlates during treatment. Overall HRQL was significantly reduced on treatment. Despite HRQL improvements over time, longitudinal studies reported a proportion of children continued to experience reduced HRQL after treatment completion. We found inconsistent associations between clinical/demographic factors and HRQL outcomes. Tentative evidence emerged for worse HRQL being associated with intensive phases of chemotherapy, corticosteroid therapy, experiencing greater toxicity, older age, and female sex. Longitudinal studies are needed to identify children at-risk of reduced HRQL.

Publication metadata

Author(s): Fardell JE, Vetsch J, Trahair T, Mateos MK, Grootenhuis MA, Touyz LM, Marshall GM, Wakefield CE

Publication type: Article

Publication status: Published

Journal: Pediatric Blood and Cancer

Year: 2017

Volume: 64

Issue: 9

Print publication date: 01/09/2017

Online publication date: 06/03/2017

Acceptance date: 18/01/2017

ISSN (print): 1545-5009

ISSN (electronic): 1545-5017

Publisher: Wiley

URL: https://doi.org/10.1002/pbc.26489

DOI: 10.1002/pbc.26489

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