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BackgroundAs part of the UK National Institute for Health and Care Excellence (NICE) single technology appraisal process, independent evidence review groups (ERGs) critically appraise a company’s submission relating to a specific technology and indication.ObjectivesTo explore the type of additional exploratory analyses conducted by ERGs and their impact on the recommendations made by NICE.MethodsThe 100 most recently completed single technology appraisals with published guidance were selected for inclusion. A content analysis of relevant documents was undertaken to identify and extract relevant data, and narrative synthesis was used to rationalize and present these data.ResultsThe types of exploratory analysis conducted in relation to companies’ models were fixing errors, addressing violations, addressing matters of judgment, and the provision of a new, ERG-preferred base case. Ninety-three of the 100 ERG reports contained at least one of these analyses. The most frequently reported type of analysis in these 93 ERG reports related to the category “Matters of judgment,” which was reported in 83 reports (89%). At least one of the exploratory analyses conducted and reported by an ERG is mentioned in 97% of NICE appraisal consultation documents and 94% of NICE final appraisal determinations, and had a clear influence on recommendations in 72% of appraisal consultation documents and 47% of final appraisal determinations.ConclusionsThese results suggest that the additional analyses undertaken by ERGs in the appraisal of company submissions are highly influential in the policy-making and decision-making process.
Author(s): Carroll C, Kaltenthaler E, Hill-McManus D, Scope A, Holmes M, Rice S, Rose M, Tappenden P, Woolacott N
Publication type: Article
Publication status: Published
Journal: Value in Health
Year: 2017
Volume: 20
Issue: 6
Pages: 785-791
Print publication date: 01/06/2017
Online publication date: 21/10/2016
Acceptance date: 17/08/2016
ISSN (print): 1098-3015
ISSN (electronic): 1524-4733
Publisher: Elsevier
URL: https://doi.org/10.1016/j.jval.2016.08.729
DOI: 10.1016/j.jval.2016.08.729
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