Browse by author
Lookup NU author(s): Professor Nicholas EmbletonORCiD, Dr Ruppa Geethanath, Dr Mithilesh Lal
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
© 2016 The British Infection Association Objective To define the clinical features and outcomes of neonatal listeriosis, and identify the maternal risk factors to seek scope for improvement. Methods Neonatal listeriosis was identified prospectively from a United Kingdom neonatal infection surveillance network (neonIN) between 2004 and 2014. The participating neonatal units completed a study-specific proforma. Results The incidence of neonatal listeriosis was 3.4 per 100,000 live births. Of the 21 cases identified, 19 were confirmed with a median gestational age of 33 weeks and a median birth weight of 1960 g. The majority had clinical features (95%, 18/19), presented within the first 24 h (95%, 18/19), and received penicillin empirically (94%, 18/19). The neonatal case-fatality rate was 21% (24% if probable cases were included). A proportion of mothers were investigated (60%, 12/18) and diagnosed with listeriosis (58%, 7/12); 32% (6/19) were treated with antibiotics but only 33% (6/12) included penicillin. Discussion Despite its rarity and the prompt and appropriate use of antibiotics neonatal listeriosis has a high case-fatality rate. There is room for improvement in the adherence to the empiric antibiotic choice for puerperal sepsis, according to the national guidelines as this, would target listeriosis. Strategies should be in place to prevent pregnancy-associated listeriosis in higher risk population.
Author(s): Sapuan S, Kortsalioudaki C, Anthony M, Chang J, Embleton ND, Geethanath RM, Gray J, Greenough A, Lal MK, Luck S, Pattnayak S, Reynolds P, Russell AB, Scorrer T, Turner M, Heath PT, Vergnano S
Publication type: Article
Publication status: Published
Journal: Journal of Infection
Year: 2017
Volume: 74
Issue: 3
Pages: 236-242
Print publication date: 01/03/2017
Online publication date: 17/11/2016
Acceptance date: 10/11/2016
ISSN (print): 0163-4453
ISSN (electronic): 1532-2742
Publisher: W.B. Saunders Ltd
URL: https://doi.org/10.1016/j.jinf.2016.11.007
DOI: 10.1016/j.jinf.2016.11.007
Altmetrics provided by Altmetric
