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Modelling the integrated regulation role of β-adrenergic signaling and CaMKII in human myocyte electrophysiological properties

Lookup NU author(s): Dr Dingchang Zheng

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Abstract

Both β-Adrenergic receptor (β-AR) signaling pathway and Ca 2+/Calmodulin-dependent protein kinase II (CaMKII) play important roles in regulating cardiac excitation-contraction coupling. However, the laboratory experiments cannot quantify these regulatory roles easily, computer models have been used as an alternative way. The aim of this study was to use computer models to preliminarily investigate the combined role of β-AR and CaMKII in human cardiac myocyte properties © 2013 CCAL.

Publication metadata

Author(s): Dai L, Zang Y, Zheng D, Luo R, Xia L

Publication type: Conference Proceedings (inc. Abstract)

Publication status: Published

Conference Name: Computing in Cardiology

Year of Conference: 2013

Pages: 389-392

Online publication date: 16/01/2014

Publisher: IEEE

URL: https://ieeexplore.ieee.org/document/6713395

Library holdings: Search Newcastle University Library for this item

ISBN: 9781479908844

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