Browse by author
Lookup NU author(s): Dr Michael DrinnanORCiD, Professor Vinidh Paleri
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
Background The purpose of this systematic review and meta-analysis was to assess the oncological and functional outcomes of transoral laser microsurgery (TLM) in radiorecurrent laryngeal cancer. Methods The review was performed using search strategies including Medline, Embase, Zetoc, conference proceedings, and a manual search. Pooled estimates of local control at 24 months, disease-free survival (DFS), and overall survival (OS) rates were calculated. Results The pooled mean estimates were: local control rate at 24 months after first TLM (n = 249), 56.9% (95% confidence interval [CI], 47.4-66.1); local control after repeat TLM (n = 186), 63.8% (95% CI, 57.1-70.2); DFS (n = 174), 70.9% (95% CI, 60.8-80); and OS (n = 276), 74.8% (95% CI, 68.2-80.9). Pooled mean laryngeal preservation (n = 286) was 72.3% (95% CI, 68.4-76.1). Conclusion TLM is oncologically sound in the salvage setting with high larynx-preservation rate, but there is a trend toward inferior local control rates compared to open partial laryngectomy techniques. Copyright © 2013 Wiley Periodicals, Inc.
Author(s): Ramakrishnan Y, Drinnan M, Kwong FNK, Grant DG, Mehanna H, Jones T, Paleri V
Publication type: Article
Publication status: Published
Journal: Head and Neck
Year: 2014
Volume: 36
Issue: 2
Pages: 280-285
Print publication date: 01/02/2014
Online publication date: 14/06/2013
Acceptance date: 24/01/2013
ISSN (print): 1043-3074
ISSN (electronic): 1097-0347
Publisher: John Wiley & Sons, Inc.
URL: https://doi.org/10.1002/hed.23291
DOI: 10.1002/hed.23291
PubMed id: 23766141
Altmetrics provided by Altmetric