Browse by author
Lookup NU author(s): Dr Gordon Strathdee
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
Human cancers frequently show altered patterns of DNA methylation, particularly at CpG islands. These CpG islands are sequences of DNA rich in CpG dinucleotides and are often found close to gene promoters. Methylation within islands has been shown to be associated with transcriptional repression of the linked gene. Genes involved in all facets of tumour development and progression can become methylated and epigenetically silenced. Re-expression of such silenced genes can lead to suppression of tumour growth or sensitisation to anticancer therapies. Agents that can reverse DNA methylation include nucleoside and non-nucleoside inhibitors of DNA methyltransferase. Such agents are now undergoing preclinical evaluation and clinical trials in cancer patients.
Author(s): Strathdee G; Brown R
Publication type: Article
Publication status: Published
Journal: Expert Opinion on Investigational Drugs
Year: 2002
Volume: 11
Issue: 6
Pages: 747-754
ISSN (print): 1354-3784
ISSN (electronic): 1744-7658
Publisher: Informa Healthcare
URL: http://dx.doi.org/10.1517/13543784.11.6.747
DOI: 10.1517/13543784.11.6.747
Altmetrics provided by Altmetric