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Lookup NU author(s): Dr Martin Picard, Dr Amy VincentORCiD, Emeritus Professor Doug Turnbull
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Clonal expansion of mtDNA deletions compromises mitochondrial function in human disease and aging, but how deleterious mtDNA genomes propagate has remained unclear. In this issue (Gitschlag et al., 2016) and in a recent Nature publication, C. elegans studies implicate the mitochondrial unfolded protein response (UPRmt) and offer mechanistic insights into this process.
Author(s): Picard M, Vincent AE, Turnbull DM
Publication type: Editorial
Publication status: Published
Journal: Cell Metabolism
Year: 2016
Volume: 24
Issue: 1
Pages: 3-4
Online publication date: 12/07/2016
Acceptance date: 01/01/1900
ISSN (print): 1550-4131
ISSN (electronic): 1932-7420
Publisher: Cell Press
URL: http://dx.doi.org/10.1016/j.cmet.2016.06.024
DOI: 10.1016/j.cmet.2016.06.024