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Lookup NU author(s): Dr Bernhard Kepplinger, Hadiza Isah, Professor Mike ProbertORCiD, Professor William Clegg, Dr Corinne Wills, Professor Michael Goodfellow, Professor Jeff ErringtonORCiD, Dr Nicholas Allenby, Dr Michael HallORCiD
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).
The actinomycete DEM20745, collected from non-rhizosphere soil adjacent to Paraserianthes falactaria trees (Cangkringan, Indonesia), is an efficient producer of the anticancer ansamycin polyketide 17-O-demethyl-geldanamycin (17-O-DMG), a biosynthetic precursor of the Hsp90 inhibitor geldanamycin (GDM). In DEM20745, 17-O-DMG is the major ansamycin product observed reaching a maximum titre of 17 mg/L in the fermentation broth. 17-O-DMG has significant potential for direct use in anticancer therapy and is a key starting material for the semi-synthesis of GDM analogues. This preferential biosynthesis of 17-O-DMG facilitates easy access to this important molecule and provides further insight the biosynthesis of the geldanamycins.
Author(s): Baksh A, Kepplinger B, Isah H, Probert MR, Clegg W, Wills C, Goodfellow M, Errington J, Allenby N, Hall MJ
Publication type: Article
Publication status: Published
Journal: Natural Product Research
Year: 2017
Volume: 31
Issue: 16
Pages: 1895-1900
Online publication date: 14/12/2016
Acceptance date: 05/11/2016
Date deposited: 25/11/2016
ISSN (print): 1478-6419
ISSN (electronic): 1478-6427
Publisher: Taylor & Francis
URL: http://dx.doi.org/10.1080/14786419.2016.1263854
DOI: 10.1080/14786419.2016.1263854
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