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Lookup NU author(s): Dr Nicholas Bown, Gavin Cuthbert, Dr David Bourn
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We conducted a retrospective population-based study of patients diagnosed with acute myeloid leukemia (AML) in northern England (population 3.1 million) in order to assess the impact of age and genetics on outcome. Four hundred and sixteen patients were diagnosed with AML, between 2007 and 2011. In those aged <= 60 years (n = 20) with acute promyelocytic leukemia (APL) overall survival (OS) was 100%. For non-APL patients aged <= 60 years, OS for those with favorable, intermediate and adverse cytogenetics was not reached, 17 and 9.8 months, respectively (p = 0.0001). Of particular note, intensively treated patients aged >60 years with intermediate cytogenetics and FLT3-/NPM1+ status had a five-year survival of 60% versus median OS of 11 months for other subsets (p = 0.04). Population-based studies reduce selection bias and have utility in studying rarer diseases, particularly in populations that recruit poorly to trials. The highly favorable outcome in our subgroup of intensively-treated FLT3-/NPM1+ older patients merits further study.
Author(s): McGregor AK, Moulton D, Bown N, Cuthbert G, Bourn D, Mathew S, Dang R, Mounter P, Jones G
Publication type: Article
Publication status: Published
Journal: Leukemia & Lymphoma
Year: 2016
Volume: 57
Issue: 7
Pages: 1575-1584
Print publication date: 01/07/2016
Online publication date: 15/12/2015
Acceptance date: 11/10/2015
ISSN (print): 1042-8194
ISSN (electronic): 1029-2403
Publisher: Taylor & Francis
URL: http://dx.doi.org/10.3109/10428194.2015.1108413
DOI: 10.3109/10428194.2015.1108413
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