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Lookup NU author(s): Dr Harshal Deshmukh
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
Aneurysmal subarachnoid haemorrhage (aSAH) is an acute cerebrovascular event with high socioeconomic impact as it tends to affect younger patients. The recent NCEPOD study looking into management of aSAH has recommended that neurovascular units in the United Kingdom should aim to secure cerebral aneurysms within 48 h and that delays because of weekend admissions can increase the mortality and morbidity attributed to aSAH.We used data from a prospective audit of aSAH patients admitted between January 2009 and December 2011. The baseline demographic and clinical features of the weekend and weekday groups were compared using the chi-squared test and T-test. Cox proportional hazards models (Proc Phreg in SAS) were used to calculate the adjusted overall hazard of in-hospital death associated with admission on weekend, adjusting for age, sex, baseline WFNS grade, type of treatment received and time from scan to treatment. Sliding dichotomy analysis was used to estimate the difference in outcomes after SAH at 3 months in weekend and weekday admissions.Those admitted on weekends had a significantly higher scan to treatment time (83.05 +/- A 83.4 h vs 40.4 +/- A 53.4 h, P < 0.0001) and admission to treatment (71.59 +/- A 79.8 h vs 27.5 +/- A 44.3 h, P < 0.0001) time. After adjustments for adjusted for relevant covariates weekend admission was statistically significantly associated with excess in-hospital mortality (HR = 2.1, CL [1.13-4.0], P = 0.01). After adjustments for all the baseline covariates, the sliding dichotomy analysis did not show effects of weekend admission on long-term outcomes on the good, intermediate and worst prognostic bands.This study provides important data showing excess in-hospital mortality of patients with SAH on weekend admissions served by the United Kingdom's National Health Service.; However, there were no effects of weekend admission on long-term outcomes.
Author(s): Deshmukh H, Hinkley M, Dulhanty L, Patel HC, Galea JP
Publication type: Article
Publication status: Published
Journal: Acta Neurochirurgica
Year: 2016
Volume: 158
Issue: 5
Pages: 829-835
Print publication date: 01/05/2016
Online publication date: 01/03/2016
Acceptance date: 15/02/2016
Date deposited: 07/06/2016
ISSN (print): 0001-6268
ISSN (electronic): 0942-0940
Publisher: Springer Wien
URL: http://dx.doi.org/10.1007/s00701-016-2746-z
DOI: 10.1007/s00701-016-2746-z
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