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Lookup NU author(s): Dr Daniel ErskineORCiD, Dr Ahmad Khundakar
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The relationship between the clinical features of dementia disorders and the resultant changes in underlying neuropathological mechanisms has long been of interest to researchers working in the field of neurodegenerative disorders. The majority of neuropathological research in dementia has utilized semi-quantitative analysis of protein inclusions, which have defined the hallmark histological features of the conditions. However, the advent of three-dimensional stereological techniques has enabled unbiased and fully quantitative assessment of brain tissue. The present review focuses on studies that have used these techniques to elucidate important relationships between neuropathological changes and clinical features and, in doing so, revealed important mechanistic insights into the pathophysiology of dementia disorders.
Author(s): Erskine D, Khundakar AA
Publication type: Review
Publication status: Published
Journal: Journal of Chemical Neuroanatomy
Year: 2016
Volume: 76
Issue: Part B
Pages: 73–81
Print publication date: 01/10/2016
Online publication date: 14/01/2016
Acceptance date: 12/01/2016
ISSN (print): 0891-0618
ISSN (electronic): 1873-6300
URL: http://dx.doi.org/10.1016/j.jchemneu.2016.01.004
DOI: 10.1016/j.jchemneu.2016.01.004
PubMed id: 26777894
