Browse by author
Lookup NU author(s): Emeritus Professor Clarke Slater
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
As mammals age, their neuromuscular junctions (NMJs) gradually change their form, acquiring an increasingly fragmented appearance consisting of numerous isolated regions of synaptic differentiation. It has been suggested that this remodelling is associated with impairment of neuromuscular transmission, and that this contributes to age-related muscle weakness in mammals, including humans. The underlying hypothesis, that increasing NMJ fragmentation is associated with impaired transmission, has never been directly tested. Here, by comparing the structure and function of individual NMJs, we show that neuromuscular transmission at the most highly fragmented NMJs in the diaphragms of old (26-28 months) mice is, if anything, stronger than in middle-aged (12-14 months) mice. We suggest that NMJ fragmentation per se is not a reliable indicator of impaired neuromuscular transmission.
Author(s): Willadt S, Nash M, Slater CR
Publication type: Article
Publication status: Published
Journal: Scientific Reports
Year: 2016
Volume: 6
Online publication date: 20/04/2016
Acceptance date: 05/04/2016
Date deposited: 20/05/2016
ISSN (electronic): 2045-2322
Publisher: Nature Publications Group
URL: http://dx.doi.org/10.1038/srep24849
DOI: 10.1038/srep24849
Altmetrics provided by Altmetric