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Lookup NU author(s): Professor Hamish McAllister-WilliamsORCiD
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Introduction or background: Depression frequently fails to respond to initial treatment.Sources of data: Predominantly meta-analyses and RCTs but supplemented where necessary by additional data and the authors' clinical experience.Areas of agreement: A systematic assessment to identify remedial causes of poor response should be followed by planned sequential treatment trials. Joint decision making by the patient and clinician is essential. Strategies with the strongest support are antidepressant augmentation with lithium or second generation antipsychotics and adding cognitive behavioural treatment. Electroconvulsive therapy is highly effective in resistant depression but there is a high relapse rate when treatment ends.Areas of controversy: Some pharmacological strategies have inconsistent data (e.g. antidepressant combinations, T3 augmentation) or limited preliminary data (e.g. ketamine, antidepressant augmentation with pramipexole). The efficacy of vagus nerve stimulation, deep brain stimulation and repetitive transcranial magnetic stimulation is unclear.Growing points: A greater understanding of the causes of depression may assist the development of more effective treatments.Areas timely for developing research: Role of glutamate antagonists and psychological treatments, other than cognitive behavioural therapy, as adjunctive treatments.
Author(s): Haddad PM, Talbot PS, Anderson IM, McAllister-Williams RH
Publication type: Article
Publication status: Published
Journal: British Medical Bulletin
Year: 2015
Volume: 115
Issue: 1
Pages: 183-201
Print publication date: 01/09/2015
Online publication date: 26/08/2015
Acceptance date: 15/07/2015
ISSN (print): 0007-1420
ISSN (electronic): 1471-8391
Publisher: Oxford University Press
URL: http://dx.doi.org/10.1093/bmb/ldv034
DOI: 10.1093/bmb/ldv034
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