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Enabling research with human embryonic and fetal tissue resources

Lookup NU author(s): Dr Steven LisgoORCiD, Emerita Professor Susan Lindsay

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Abstract

Congenital anomalies are a significant burden on human health. Understanding the developmental origins of such anomalies is key to developing potential therapies. The Human Developmental Biology Resource (HDBR), based in London and Newcastle, UK, was established to provide embryonic and fetal material for a variety of human studies ranging from single gene expression analysis to large-scale genomic/transcriptomic studies. Increasingly, HDBR material is enabling the derivation of stem cell lines and contributing towards developments in tissue engineering. Use of the HDBR and other fetal tissue resources discussed here will contribute to the long-term aims of understanding the causation and pathogenesis of congenital anomalies, and developing new methods for their treatment and prevention.

Publication metadata

Author(s): Gerrelli D, Lisgo S, Copp AJ, Lindsay S

Publication type: Editorial

Publication status: Published

Journal: Development

Year: 2015

Volume: 142

Issue: 18

Pages: 3073-3076

Print publication date: 01/09/2015

Acceptance date: 01/01/1900

ISSN (print): 0950-1991

ISSN (electronic): 1477-9129

Publisher: Company of Biologists Ltd

URL: http://dx.doi.org/10.1242/dev.122820

DOI: 10.1242/dev.122820

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