Browse by author
Lookup NU author(s): Professor Hermano Krebs
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
Objective:The nonlesioned motor cortex (M1(NL)) is thought to be hyperexcitable in patients with subacute or chronic stroke and offers a promising therapeutic target. However, whether M1(NL) excitability behaves the same for subcortical and cortical strokes is unknown. The aim of the present study was to determine whether cortical, or purely subcortical, strokes have a different effect on M1(NL) excitability.Methods:We looked for correlations between the Fugl-Meyer (FM) score and M1(NL) resting motor threshold (RMTNL) in 34 stroke survivors classified according to lesion location (cortico-subcortical or purely subcortical). In addition to the FM, the Wolf Motor Score and motor power were measured.Results:FM correlated with RMTNL for subcortical (r = 0.82; p = 0.001) but not for cortical strokes (r = 0.11; p = 0.62). Likewise, Wolf Motor Score (r = -0.62; p = 0.03) and motor power (r = 0.64; p = 0.023) were correlated with RMTNL for the subcortical group, but not for the cortical group.Conclusion:We show that the impact on M1(NL) depends on lesion location and conclude that protocols aimed at reducing M1(NL) cortical excitability may be worth exploring for subcortical but not for cortical stroke.
Author(s): Thickbroom GW, Cortes M, Rykman A, Volpe BT, Fregni F, Krebs HI, Pascual-Leone A, Edwards DJ
Publication type: Article
Publication status: Published
Journal: Neurology
Year: 2015
Volume: 85
Issue: 6
Pages: 517-520
Print publication date: 11/08/2015
Online publication date: 17/07/2015
Acceptance date: 10/04/2015
ISSN (print): 0028-3878
ISSN (electronic): 1526-632X
Publisher: Lippincott Williams & Wilkins
URL: http://dx.doi.org/10.1212/WNL.0000000000001828
DOI: 10.1212/WNL.0000000000001828
Altmetrics provided by Altmetric
