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Lookup NU author(s): Dr Huai Seng Loh
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Objective. Anhedonia is the reduced ability to experience pleasure. It is a core symptom of depression and is particularly difficult to treat. This study aims to compare the level of anhedonia between depressed patients on anti-depressants and healthy subjects. Method. A total of 111 depressed patients on selective serotonin reuptake inhibitor (SSRI) and 82 healthy subjects were recruited from the outpatient psychiatric services at two major general hospitals in a cross-sectional study. Subjects were assessed using the Mini International Neuropsychiatric Interview 5.0.0 or MINI, Beck's Depression Index (BDI), and Snaith-Hamilton Pleasure Scale (SHAPS). Relevant personal and sociodemographic information were also collected. Results. There was a significant association between educational level and SHAPS-M scores (P < 0.01) among the participants. Most items in the SHAPS scores were significantly different (P < 0.01) in the depressed subjects treated with anti-depressant compared with the healthy subjects, aft er adjusting the confounding factors, BDI score, and educational level. Conclusion. Anhedonia oft en persists in depressed patients despite on SSRI anti-depressant treatment.
Author(s): Yee A, Chin SC, Hashim AHB, Singh MKAPH, Loh HS, Sulaiman AH, Ng CG
Publication type: Article
Publication status: Published
Journal: International Journal of Psychiatry in Clinical Practice
Year: 2015
Volume: 19
Issue: 3
Pages: 182-187
Online publication date: 15/04/2015
Acceptance date: 28/02/2015
ISSN (print): 1365-1501
ISSN (electronic): 1471-1788
Publisher: Taylor & Francis
URL: http://dx.doi.org/10.3109/13651501.2015.1031139
DOI: 10.3109/13651501.2015.1031139
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