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Short stature and pubertal delay in Duchenne muscular dystrophy

Lookup NU author(s): Dr Claire WoodORCiD, Professor Volker StraubORCiD, Professor Michela GuglieriORCiD, Emerita Professor Katherine Bushby, Professor Timothy Cheetham

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Abstract

Children with Duchenne muscular dystrophy (DMD) are shorter than their healthy peers. The introduction of corticosteroid (CS) has beneficial effects on muscle function but slows growth further and is associated with pubertal delay. In contrast to CS usage in most children and adolescents, weaning glucocorticoid is not a key objective of management in DMD. As the outlook for these young people improves, one of the main challenges is to reduce or offset the detrimental effects of CS on growth and development. This is a review of the aetiology and prevalence of short stature and delayed puberty in DMD, a summary of the treatments available and suggestions for areas of further research.

Publication metadata

Author(s): Wood CL, Straub V, Guglieri M, Bushby K, Cheetham T

Publication type: Review

Publication status: Published

Journal: Archives of Disease in Childhood

Year: 2016

Volume: 101

Issue: 1

Pages: 101-106

Print publication date: 01/01/2016

Online publication date: 03/07/2015

Acceptance date: 16/06/2015

ISSN (print): 0003-9888

ISSN (electronic): 1468-2044

Publisher: BMJ PUBLISHING GROUP

URL: http://dx.doi.org/10.1136/archdischild-2015-308654

DOI: 10.1136/archdischild-2015-308654

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