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Effect of access site, gender, and indication on clinical outcomes after percutaneous coronary intervention: Insights from the British Cardiovascular Intervention Society (BCIS)

Lookup NU author(s): Professor Vijay KunadianORCiD, Professor Azfar Zaman, Dr Mark De Belder

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Abstract

Background Gender is a strong predictor of periprocedural major bleeding complications after percutaneous coronary intervention (PCI). The access site represents an important site of such bleeding complications, which has driven adoption of the transradial access (TRA) use during PCI, although female gender is an independent predictor of transradial PCI failure. This study sought to define gender differences in access site practice and study associations between access site choice and clinical outcomes for PCI over a 6-year period, through the analysis of the British Cardiovascular Intervention Society observational database.Methods and Results In-hospital major adverse cardiovascular events (a composite of in-hospital mortality and in-hospital myocardial reinfarction and target vessel revascularization), in-hospital bleeding complications, and 30-day mortality were studied based on gender and access site choice (transfemoral access, TRA) in 412,122 patients who underwent PCI between 2007 and 2012 in the United Kingdom. Use of TRA increased in both genders over time, although this lagged behind in women (21% in 2007 to 58% in 2012) compared with men (24% in 2007 to 64% in 2012). In both men and women, TRA was independently associated with a lower in-hospital major adverse cardiovascular event (odds ratio [OR] 0.82, 95% CI 0.76-0.90; OR 0.75, 95% CI 0.66-0.84), in-hospital major bleeding (OR 0.54, 95% CI 0.44-0.66; OR 0.26, 95% CI 0.200.33), and 30-day mortality (OR 0.80, 95% CI 0.73-0.89; OR 0.82, 95% CI 0.71-0.94), respectively.Conclusions Where possible, TRA should be considered as the preferred access site choice for PCI, particularly in women in whom the greatest reductions bleeding end points were observed across all indications.

Publication metadata

Author(s): Kwok CS, Kontopantelis E, Kunadian V, Anderson S, Ratib K, Sperrin M, Zaman A, Ludman PF, De Belder MA, Nolan J, Mamas MA, Natl Inst Cardiovasc Outcomes Res, British Cardiovasc Intervention So

Publication type: Article

Publication status: Published

Journal: American Heart Journal

Year: 2015

Volume: 170

Issue: 1

Pages: 164-172.e5

Print publication date: 01/07/2015

Online publication date: 18/04/2015

Acceptance date: 14/04/2015

ISSN (print): 0002-8703

ISSN (electronic): 1097-5330

Publisher: Mosby, Inc.

URL: http://dx.doi.org/10.1016/j.ahj.2015.04.018

DOI: 10.1016/j.ahj.2015.04.018

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