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Oral anticoagulation: a critique of recent advances and controversies

Lookup NU author(s): Professor Farhad Kamali, Professor Ann DalyORCiD

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Abstract

There have recently been significant advances in the field of oral anticoagulation, but these have also led to many controversies. Warfarin is still the commonest drug used for clotting disorders but its use is complicated owing to wide inter-individual variability in dose requirement and its narrow therapeutic index. Warfarin dose requirement can be influenced by both genetic and environmental factors. Two recent randomized controlled trials (RCTs) came to different conclusion regarding the utility of genotype-guided dosing; we critically explore the reasons for the differences. The new generation of oral anticoagulants have been demonstrated to be as efficacious as warfarin, but further work is needed to evaluate their safety in real clinical settings.

Publication metadata

Author(s): Pirmohamed M, Kamali F, Daly AK, Wadelius M

Publication type: Review

Publication status: Published

Journal: Trends in Pharmacological Sciences

Year: 2015

Volume: 36

Issue: 3

Pages: 153-163

Print publication date: 01/03/2015

Online publication date: 17/02/2015

ISSN (print): 0165-6147

ISSN (electronic): 1873-3735

Publisher: ELSEVIER SCIENCE LONDON

URL: http://dx.doi.org/10.1016/j.tips.2015.01.003

DOI: 10.1016/j.tips.2015.01.003

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