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Lookup NU author(s): Professor Heinz Grunze
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Katayama and colleagues proposed in their article a therapeutic window for lamotrigine in affective disorders between 5 and 11g/mL. Despite potential differences in lamotrigine metabolism, the results of their retrospective study in a Japanese population match nicely with what we have previously reported in a Caucasian population with rapid cycling bipolar disorder. It is suggested that not only in epilepsy, but also in mood-disordered patients clinicians should rather consider lamotrigine plasma levels than dosage when in doubt about the efficacy of treatment.
Author(s): Grunze H, Walden J
Publication type: Letter
Publication status: Published
Journal: Pharmacopsychiatry
Year: 2014
Volume: 47
Issue: 7
Pages: 268-269
Print publication date: 01/11/2014
ISSN (print): 0176-3679
ISSN (electronic): 1439-0795
Publisher: GEORG THIEME VERLAG KG
URL: http://dx.doi.org/10.1055/s-0034-1390413
DOI: 10.1055/s-0034-1390413