Browse by author
Lookup NU author(s): Emeritus Professor John Davison
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
Transplantation affords recipients the potential for a full life and, for some, parenthood. Female transplant recipients must continue to take immunosuppression during pregnancy and breast-feeding. This article reviews case and series reports regarding breast-feeding in those taking transplant medications. Avoidance of breast-feeding has been the customary advice because of the potential adverse effects of immunosuppressive exposure on the infant. Subsequent studies have demonstrated that not all medication exposure translates to risk for the infant, that the exposure in utero is greater than via breast milk and that no lingering effects due to breast-feeding have been found to date in infants who were breast-fed while their mothers were taking prednisone, azathioprine, cyclosporine, and/or tacrolimus. Thus, except for those medications where clinical information is inadequate (mycophenolic acid products, sirolimus, everolimus, and belatacept), the recommendation for transplant recipients regarding breastfeeding has evolved into one that is cautiously optimistic. (C) 2014 Elsevier Ltd. All rights reserved.
Author(s): Constantinescu S, Pai A, Coscia LA, Davison JM, Moritz MJ, Armenti VT
Publication type: Article
Publication status: Published
Journal: Best Practice & Research Clinical Obstetrics & Gynaecology
Year: 2014
Volume: 28
Issue: 8
Pages: 1163-1173
Print publication date: 01/11/2014
ISSN (print): 1521-6934
ISSN (electronic): 1532-1932
Publisher: Elsevier
URL: http://dx.doi.org/10.1016/j.bpobgyn.2014.09.001
DOI: 10.1016/j.bpobgyn.2014.09.001
PubMed id: 25271063
Altmetrics provided by Altmetric