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Lookup NU author(s): Professor Heinz Grunze
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Background: There is growing research interest in studying motivational deficits in different neuropsychiatric disorders because these symptoms appear to be more common than originally reported and negatively impact long-term functional outcomes. However, there is considerable ambiguity in the terminology used to describe motivational deficits in the scientific literature. For the purposes of this manuscript, the term "amotivation" will be utilised in the context of mood disorders, since this is considered a more inclusive/appropriate term for this patient population.Other challenges impacting the study of amotivation in mood disorders, include: appropriate patient population selection; managing or controlling for potential confounding factors; the lack of goldstandard diagnostic criteria and assessment scales; and determination of the most appropriate study duration.Methods: This paper summarises the search for a consensus by a group of experts in the optimal approach to studying amotivation in mood disorders. Results: The consensus of this group is that amotivation in mood disorders is a legitimate therapeutic target, given the magnitude of the associated unmet needs, and that proof-of-concept studies should be conducted in order to facilitate subsequent larger investigations. The focus of this manuscript is to consider the study of amotivation, as a residual symptom of major depressive disorder (MDD) or bipolar depression (BD), following adequate treatment with a typical antidepressant or mood stabiliser/ antipsychotic, respectively.Discussion: There is a paucity of data studying amotivation in mood disorders. This manuscript provides general guidance on the most appropriate study design(s) and methodology to assess potential therapeutic options for the management of residual amotivation in mood disorders. (C) 2014 Elsevier By, All rights reserved.
Author(s): Calabrese JR, Fava M, Garibaldi G, Grunze H, Krystal AD, Laughren T, Macfadden W, Marin R, Nierenberg AA, Tohen M
Publication type: Review
Publication status: Published
Journal: Journal of Affective Disorders
Year: 2014
Volume: 168
Pages: 439-451
Print publication date: 15/10/2014
Online publication date: 10/07/2014
Acceptance date: 24/06/2014
ISSN (print): 0165-0327
ISSN (electronic): 1573-2517
Publisher: ELSEVIER SCIENCE BV
URL: http://dx.doi.org/10.1016/j.jad.2014.06.056
DOI: 10.1016/j.jad.2014.06.056
