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Cell cycle regulation in human embryonic stem cells: links to adaptation to cell culture

Lookup NU author(s): Dr Tomas Barta

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Abstract

Cell cycle represents not only a tightly orchestrated mechanism of cell replication and cell division but it also plays an important role in regulation of cell fate decision. Particularly in the context of pluripotent stem cells or multipotent progenitor cells, regulation of cell fate decision is of paramount importance. It has been shown that human embryonic stem cells (hESCs) show unique cell cycle characteristics, such as short doubling time due to abbreviated G1 phase; these properties change with the onset of differentiation. This review summarizes the current understanding of cell cycle regulation in hESCs. We discuss cell cycle properties as well as regulatory machinery governing cell cycle progression of undifferentiated hESCs. Additionally, we provide evidence that long-term culture of hESCs is accompanied by changes in cell cycle properties as well as configuration of several cell cycle regulatory molecules.

Publication metadata

Author(s): Barta T, Dolezalova D, Holubcova Z, Hampl A

Publication type: Article

Publication status: Published

Journal: Experimental Biology and Medicine

Year: 2013

Volume: 238

Issue: 3

Pages: 271-275

Print publication date: 01/03/2013

ISSN (print): 1535-3702

ISSN (electronic): 1535-3699

Publisher: Sage

URL: http://dx.doi.org/10.1177/1535370213480711

DOI: 10.1177/1535370213480711

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